Drying & Extraction

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Filtration
 
Filtration  Platforms  from  ESCO Labor Switzerland ,  made of Stainless steel 316 and Hastalloy  With highest standards as used in pharmaceutical manufacturing .
Complete set up for the lab and R&D , and up to production scales  500L batch .
Including complete control, lift device , filling systems, vacuum for continues drying, and other customization by request. 

• Stainless steel head with supporting structure for the glass column
• Integrated on a trolley, wall mounted or on a fixed table/floor stand
• Easily accessible and visible glass process column and cyclone set-up
• High process yields (>90%) from 1ml (10 mg) to 24 liters/8 hours
• Particles from 1-150µm
• PC control with real-time trending and excel date reporting
• Water and organic solvents
• Chilling or congealing; waxes, polymers, carbohydrates, …
• Provision for product cooling for very temperature sensitive or low glass transition temperature products
• Critical process data such as temperatures, pressures and liquid/gas speeds are handled by the control unit
• Nitrogen recirculation system for oxygen sensitive materials, environmental requirements or drying of high quantities organic solvents
• Unit can be used for pre-clinical and clinical applications

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Vacuum Drying

Fully integrated and automated “glass” lab scale Agitated Vacuum Dryer. For early-stage vacuum drying kinetic studies of API / NCE, scale-up and process validation. 

• Variable speed impeller
• Breaker
• Glass process vessel of 1900 ml. for 350 - 1.400 ml./batch ( 5 different vessel-sets available to cover 50 - 3.800 ml.)
• Vacuum system; dust filter, glass condenser, bypass, vacuum pump, process pressure control
• Nitrogen purge
• The system can be build on a frame to be incorporated in a hood
• Critical process data: impeller torque, product temperature, impeller speed, process pressure, mass recovered liquid, process vessel/condenser/filter jacket temperature, mass recovered liquid, RH (optional), vapour temp (optional)
• PC/PLC automation package: "real-time"-trending and batch reporting in Excel of all critical process data and batch identification
• See video at http://www.procept.be/lab-vac

• Combination of plexi and glass for excellent process transparency
• Integrated on a trolley, wall mounted or on a fixed table/floor stand
• Easy connections for a fast change in set-up to air handling module and controls
• Monitoring and control of all critical parameter
• System in negative pressure for operator and product safety
• Glass process vessels: 1 or 4 liters set-up
• Easy (in process) filling, discharging and sampling in process
• Water and organic solvents
• Melt processing; waxes, polymers
• Nitrogen recirculation for oxygen sensitive materials, environmental requirements or drying of high quantities organic solvents
• Unit can be used for pre-clinical and clinical applications

Liquid CO2 from the storage is pressurized, heated and transferred to the extractor, where it gets loaded according to adjusted conditions. A change of these conditions (pressure, temperature) causes precipitation of the dissolved substances in the separation vessels. The now gaseous CO2 is condensed, intermediately stored and recycled again.

Gases in fluid condition (above the critical pressure and the critical temperature) dissolve larger quantities of substances than the partial pressure of the substance in the solvent normally permits
CO2 is an UNPOLAR solvent, which results in a high solubility for non polar and low polar substances up to a molecular weight of 250
Solubility decreases with increasing polarity
High polar substances are insoluble
The raw material is exposed to the fluid and soluble substances are transferred into it
Separation is achieved by change of parameters or adsorption